Newcastle Study Reverses Diabetes

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Re: Newcastle Study Reverses Diabetes

Post by Lovebird on Sat Jan 20, 2018 2:00 am

This should answer many questions raised:

https://link.springer.com/article/10.1007/s00125-017-4504-z?wt_mc=alerts.TOCjourn

Translating aetiological insight into sustainable management of type 2 diabetes by dr. Roy Taylor

One

"To induce weight loss, a liquid formula diet provided in individual meal sachets was used (2.51 MJ [600 kcal]/day; three sachets). To minimise constipation, up to 240 g/day of non-starchy vegetables were allowed. The total energy intake was thus around 2.93 MJ (700 kcal)/day. A relatively high sugar content was necessary for palatability, but this did not prevent normalisation of fasting plasma glucose within 7 days despite withdrawal of oral hypoglycaemic agents [2]. Unexpectedly, the dietary approach adopted to allow the hypothesis to be tested was actually liked by the participants.

Counterbalance demonstrated that the individuals who did not return to non-diabetic blood glucose control typically had a longer disease duration, but notably already had severely impaired beta cell function at baseline [9]. Weight loss produced normalisation of liver fat content with normalisation of hepatic insulin sensitivity in all, but this alone was insufficient to normalise glucose control. The apparent heterogeneity of response lay in the duration-dependent progression to complete beta cell de-differentiation, whereby those individuals with beta cells still at the reversible stages could achieve complete re-differentiation and resumption of beta cell specialist function [7].

All participants reported almost complete lack of hunger within 1–2 days of commencing the diet. This is striking during achievement of ~ 15 kg weight loss. Notable wellbeing was reported [37]. Several participants wished to continue the low-energy liquid diet after the 8 week period of the study to meet their own weight target."

Two

"So which dietary strategy is most appropriate?

Over recent years nutrition guidelines have moved away from prescriptive macronutrient content towards a more person-centred philosophy, acknowledging that there is no ‘one best diet’ for diabetes [50]. Three evidenced approaches (low carbohydrate, Mediterranean and intermittent energy restriction) are discussed in the following section as potential options for a maintenance diet following the initial rapid weight loss period.

As different dietary approaches are likely to suit the needs and preferences of different individuals (especially those who have had little success with conventional low-fat diets), a decision aid such as that developed to facilitate informed choices about diabetes medications may be a useful tool. Long-term weight control will be most effectively achieved by finding an approach to eating that an individual, and their family, can sustain. The composition (restricted carbohydrate/restricted fat) is far less important than the overall quantity of food, and there are varying, equally valid ways of achieving this goal."

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Re: Newcastle Study Reverses Diabetes

Post by Heuristicfireflower on Sat Jan 27, 2018 7:25 pm

In the range of 825-850 lcal/day 59% of carb kcal amounts to a range of 486 - 501 cals giving about 121 to 125gms of carbs intake per day.  At 700 kcals the carb total is about 103gms. I would think these were way below the previous carb intake for the group before the intervention and in Mark's graph this, at least, keeps weight stasis.

The carb intake was lowered along with the total calories to a normal amount even though the percentage of carbs was quite high.  Indications would still favor lowered insulin response at this level.
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Re: Newcastle Study Reverses Diabetes

Post by sharperhawk on Sat Jan 27, 2018 8:22 pm

Mark Sisson was on Jimmy Moore's show last September. Mark said that if he ate more carbs one day, he is right back into ketosis the next day after a little IF and a workout. Jimmy said that he was jealous and couldn't do that.

Mark said: "So what do you think your daily caloric intake is right now?"

Jimmy said about 2500 calories.

Mark: "What happens if you go down to 1800?"

Jimmy said it depends on food quality. Do calories really matter?

Mark: Yes.

So why is Mark Sisson talking about calories? Maybe his carb curve graph should be taken with a shaker full of salt.

Jimmy Moore reportedly eats well under 50 grams of carbs per day. He should be a fat burning machine. He probably is burning fat—the fat he eats in great abundance.

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Re: Newcastle Study Reverses Diabetes

Post by Lovebird on Sun Jan 28, 2018 5:11 am

Pretty much every successful health/diet strategy recommends eating whole, minimally processed, nutrient-rich foods. And this is where JM goes wrong. And has gone wrong in the past.

Because he cares more about his business than his health. Obviously.

Like MS cares most about his business. Despite all his claims stating otherwise.

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Re: Newcastle Study Reverses Diabetes

Post by sharperhawk on Sun Jan 28, 2018 9:28 am

Lovebird wrote:Pretty much every successful health/diet strategy recommends eating whole, minimally processed, nutrient-rich foods. And this is where JM goes wrong.

The Newcastle study participants were not eating whole foods. They were drinking shakes.

For almost all whole foods - non-starchy vegetables being the exception - if you overeat them, you will gain weight. It's harder to overeat whole foods, but some people can and do.
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