Is your size a pre-determined factor?

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Is your size a pre-determined factor?

Post by ONTARIO on Mon Nov 05, 2018 4:47 pm

Just something I found interesting when surfing the internet news. It is a news article about a study that was done using mice (of course!) to see if obesity or increased fat accumulation is linked to genes.

https://lfpress.com/news/local-news/western-university-researchers-chubby-mice-show-obesity-linked-to-genes

I have always thought that size does have some gene component to it. Sure, diet and exercise matter but some people (women sizes used here)  are just never going to be a size 2 just like others are never going to be a size 20.

I'll have to see if I can get a copy of the actual study once it's released. It would be interesting to read.

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Re: Is your size a pre-determined factor?

Post by Lovebird on Tue Nov 06, 2018 12:03 am

Ontario wrote:I'll have to see if I can get a copy of the actual study once it's released. It would be interesting to read.

That's easy... Very Happy Here you go:

https://www.nature.com/articles/s41598-018-34234-9

Pannexin 1 regulates adipose stromal cell differentiation and fat accumulation. Scientific Reports, 2018; 8
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Re: Is your size a pre-determined factor?

Post by perennialpam on Tue Nov 06, 2018 6:17 am

LB - you are a research extraordinaire, I swear!
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Re: Is your size a pre-determined factor?

Post by sharperhawk on Wed Nov 07, 2018 12:27 pm

Genes have some influence on pretty much everything.

I take issue with "predetermined." Obesity is not predetermined. There may be a lower limit on how small you can be, given adequate food. There is no upper limit on how big you can become. That is why we see every First World country becoming more obese. The genes haven't changed that much in a few decades. Food prices, food convenience, and how much physical activity is part of our mandatory routines have changed.
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Re: Is your size a pre-determined factor?

Post by Rig D on Wed Nov 07, 2018 1:28 pm

^ 100% agree. You just have to do the best you can working with the genetic hand you were dealt with 9 months before birth.

I've always been way, way too short for my weight, going all the way back to being too big for Pop Warner football at age 10.

I've always found the BMI charts to be pretty humourous points of reference. Michael Jordon, in his prime was overweight, there's no hope for me.
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Re: Is your size a pre-determined factor?

Post by Paysan on Thu Nov 29, 2018 4:53 pm

I'm another under-height shortie; so I started to read that article ... till my eyes crossed. Did anyone notice that on the high-fat (60%) chow, the mice basically weighed the same? That cell growth was slower in the KO mice, but it didn't seem to slow them down any. KO mice were simply more active, even with a thicker layer of fat. This could be attributed to higher glucose and insulin levels. But a couple of key questions which I couldn't find answers to (or else my eyes crossed too soon) were: What effect, if any , was observed in their life spans? were they more subject to the ills of life in general than their controls?
My fluid takeway from that article was: A high fat (good fats) diet might pad your ribs a bit more, but essentially you maintain a normal weight and an active lifestyle. Isn't that what we strive for? Genes are important, but not a death sentence.

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